ParkinsonCanadaV1, France, Analysis, bibRecord, 000068

Apathy in Parkinson's disease: clinical features, neural substrates, diagnosis, and treatment.

Identifieur interne : 000068 ( France/Analysis ); précédent : 000067; suivant : 000069

Apathy in Parkinson's disease: clinical features, neural substrates, diagnosis, and treatment.

Auteurs : Javier Pagonabarraga [Espagne] ; Jaime Kulisevsky [Espagne] ; Antonio P. Strafella [Canada] ; Paul Krack [France]

Source :

The Lancet. Neurology [ 1474-4465 ] ; 2015.

RBID : pubmed:25895932

English descriptors

KwdEn :
- Apathy, Humans, Male, Middle Aged, Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Parkinson Disease (therapy).
MESH :
- diagnosis : Parkinson Disease.
- physiopathology : Parkinson Disease.
- therapy : Parkinson Disease.
- Apathy, Humans, Male, Middle Aged.

Abstract

Normal maintenance of human motivation depends on the integrity of subcortical structures that link the prefrontal cortex with the limbic system. Structural and functional disruption of different networks within these circuits alters the maintenance of spontaneous mental activity and the capacity of affected individuals to associate emotions with complex stimuli. The clinical manifestations of these changes include a continuum of abnormalities in goal-oriented behaviours known as apathy. Apathy is highly prevalent in Parkinson's disease (and across many neurodegenerative disorders) and can severely affect the quality of life of both patients and caregivers. Differentiation of apathy from depression, and discrimination of its cognitive, emotional, and auto-activation components could guide an individualised approach to the treatment of symptoms. The opportunity to manipulate dopaminergic treatment in Parkinson's disease allows researchers to study a continuous range of motivational states, from apathy to impulse control disorders. Parkinson's disease can thus be viewed as a model that provides insight into the neural substrates of apathy.

DOI: 10.1016/S1474-4422(15)00019-8
PubMed: 25895932

Affiliations:

Links to Exploration step

pubmed:25895932

Le document en format XML

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La maladie de Parkinson au Canada (serveur d'exploration)

Apathy in Parkinson's disease: clinical features, neural substrates, diagnosis, and treatment.

Apathy in Parkinson's disease: clinical features, neural substrates, diagnosis, and treatment.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.